Scholars 2007

2007 Future - Quest for Energy

Amunts Alexey Michael

amunts alexey

Tel Aviv University, Biochemistry Department

Update July 2018

PROFESSIONAL DEVELOPMENT

2005 – 2010 Ph.D (Dan David scholarship for outstanding students)
Department of Biochemistry, Tel Aviv University, Israel.
Ph.D thesis – "Structural analysis of plant Photosystem I".
Advisor: Nathan Nelson

2011 – 2015 Postdoctoral fellow (Marie Curie, HFSP long term fellowships)
MRC Laboratory of Molecular Biology, Cambridge, UK.
"Structural characterization of mitochondrial ribosome".
Advisor: Venki Ramakrishnan

2016 – Tenure-track group leader (Assistant Professor)
SciLifeLab Fellow
Department of Biochemistry and Biophysics, Stockholm University.
Stockholm, Sweden.

2018 – Director of the SciLifeLab research program for Biology of Molecular Interactions
The program comprises 23 research groups focusing on structural biology, proteomics and drug discovery

ACADEMIC AWARDS

2014 Churchill College Fellow. Cambridge, UK.
2015 George Palade Award for biological microscopy.
Microscopy Society of America (MSA).
2016 Lennart Nilsson Award for scientific imaging.
Karolinska Institutet, Sweden.

RESEARCH INTERESTS

- To establish principles of protein synthesis, folding and assembly in bioenergetic membranes of organelles.
- Structural investigation of multi-component complexes that are at the heart of biological processes.

TEACHING RESPONSIBILITIES

- Structural Biochemistry course, 15 ECTS for advanced undergraduate and Master students

FUNDING SOURCES

- European Research Council (ERC), Strategic Research Area (SFO), Swedish Foundation for Strategic Research future
leaders program (SSF), Ragnar Söderberg fellowship in medicine, Cancer Society young investigator award, Swedish
Research Council, SciLifeLab development project, Horizon 2020 innovative training network.

PARTNERS

- AstraZeneca: Anglo–Swedish biopharmaceutical company.
- MAX IV Laboratory: next-generation synchrotron radiation facility.
- Interspectral AB: spin-off company for 3D visualization and volumetric rendering.

REVIEWER EXPERIENCE
- Reviewer for: Science, Nature, Cell, Nature Struct & Mol Biology, J. of Cell Biol, Plant Cell, Nature Comm
- Grant reviewer for: ERC, BBSRC (UK), ANR (France), ISF (Israel)

Update December 2016

Alexey Amunts’ research group

Lennart Nilsson Award for scientific imaging

Personal Details: 

Assistant Professor at Stockholm University. Head of the Swedish national Cryo-EM laboratory at SciLifeLab
Email:amunts@scilifelab.se

Research Interests:

Our group at SciLifeLab explores the frontiers of the currently developing cryo-EM methodology to visualize macromolecules that play key roles in fundamental and medically relevant cellular processes. We focus on technically challenging subjects, for which the molecular mechanisms have been least understood.

One of the ongoing projects is to determine structural basis for the elusive system of protein synthesis in mitochondria. Additionally, we have a special interest in membrane proteins and bioenergetics related complexes, where intrinsic flexibility and dynamic properties underlie functional characteristics.

July, 2015

Updated reserach interest

My research group at the SciLifeLab (Stockholm) explores the frontiers of the developing cryo-EM methods to visualize otherwise intractable molecular complexes that play key roles in fundamental cellular processes. Particularly, we have specialized in defining intact atomic structures of human Mitoribosome in its near-native states. The results have important implications for human health, as it provide a reference for analysis of mutations that cause severe pathologies, and for future drug design. The next goal is to conduct comparative structural studies of Mitoribosomes at different functional stages and from various organisms, in order to gain further insights into their mechanism of action, evolution, assembly and medical importance.

Title of Research: 

"The Crystal Structure of Plant Photosystem I Complex: Towards Atomic Resolution"

Summary of Research, September 2007

Updated CV 2015

Updated March 10, 2014

My research in Venki Ramakrishnan lab aims to establish principles of protein synthesis in mitochondria. Particularly, using single particle electron cryo-microscopy, we have specialized in defining intact atomic structures of mitochondrial ribosomes in their native environment. Comparative structural studies of mitochondrial ribosomes at different functional states and from variable organisms, gain insights into their mechanism of action, evolution, assembly and medical importance.