Scholars 2007

2007 Future - Quest for Energy

Amunts Alexey Michael

amunts alexey

Personal Details: 
Biochemistry Department, Tel Aviv University, Israel

Update December 2016

Alexey Amunts’ research group

Lennart Nilsson Award for scientific imaging

Personal Details: 
Assistant Professor at Stockholm University. Head of the Swedish national Cryo-EM laboratory at SciLifeLab
Email:amunts@scilifelab.se

Amunts Alexey Michael Resume

Research Interests:
Our group at SciLifeLab explores the frontiers of the currently developing cryo-EM methodology to visualize macromolecules that play key roles in fundamental and medically relevant cellular processes. We focus on technically challenging subjects, for which the molecular mechanisms have been least understood.
One of the ongoing projects is to determine structural basis for the elusive system of protein synthesis in mitochondria. Additionally, we have a special interest in membrane proteins and bioenergetics related complexes, where intrinsic flexibility and dynamic properties underlie functional characteristics.

July, 2015

Updated reserach interest

My research group at the SciLifeLab (Stockholm) explores the frontiers of the developing cryo-EM methods to visualize otherwise intractable molecular complexes that play key roles in fundamental cellular processes. Particularly, we have specialized in defining intact atomic structures of human Mitoribosome in its near-native states. The results have important implications for human health, as it provide a reference for analysis of mutations that cause severe pathologies, and for future drug design. The next goal is to conduct comparative structural studies of Mitoribosomes at different functional stages and from various organisms, in order to gain further insights into their mechanism of action, evolution, assembly and medical importance.

 

Title of Research: 
"The Crystal Structure of Plant Photosystem I Complex: Towards Atomic Resolution"
Summary of Research, September 2007

Updated CV 2015

Updated March 10, 2014
My research in Venki Ramakrishnan lab aims to establish principles of protein synthesis in mitochondria. Particularly, using single particle electron cryo-microscopy, we have specialized in defining intact atomic structures of mitochondrial ribosomes in their native environment. Comparative structural studies of mitochondrial ribosomes at different functional states and from variable organisms, gain insights into their mechanism of action, evolution, assembly and medical importance.