Scholars 2012

2012 Future - Genome Research

Gelfman Sahar


Tel Aviv University, Department of Human Molecular Genetics and Biochemistry

“The Influence of Evolutionary Changes in Gene Structure and Epigenetic Modifications on the Alternative Splicing Mechanism”

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January 2017

My PhD was concluded in 2014, and was followed by a short, 1 year post-doc at Duke University, NC, where I focused on human genetics and variation. Currently I am a research associate at Columbia University Medical Center, NY; I lead the group’s analysis team focusing on neuropsychiatric disorders modelling and drug screening using multi electrode arrays. My role includes strategic planning, development of analysis tools and writing results for publications. My role as a computational geneticist at IGM includes developing tools for identification of damaging variants, such as the TraP tool for annotating pathogenic non-coding variants ( as well as genomic interpretations of exomes and whole genomes of patients with undiagnosed disorders.

My updated publication list:

McSweeney, K.M., A.B. Gussow, S. Bradrick, S. Petrovski, W. N. Frankel, S. Gelfman, Q. Wang and D. B. Goldstein. 2016. Inhibition of microRNA-128 promotes excitability of cultured neuronal networks. Genome Research, 26: 1411-1416.

Bell, R.E., T. Golan, D. Sheinboim, H. Malcov, D. Amar, A. Salamon, T. Liron, S. Gelfman, Y. Gabet, R. Shamir and C. Levy. 2016. Enhancer methylation dynamics contribute to cancer plasticity and patient mortality. Genome Research, 26: 601-611.

Gelfman, S*, A. Yearim*, R. Shayevitch, S. Melcer, O. Glaich, J.P. Mallm, … E. Meshorer and G. Ast. 2015. HP1 is involved in regulating the global impact of DNA methylation on alternative splicing. Cell Reports, 10.7: 1122-1134. *Both authors contributed equally.

Gelfman, S. and G. Ast. 2013. When epigenetics meets alternative splicing: the roles of DNA methylation and GC architecture. Epigenomics, 5.4: 351-353. Editorial.

Gelfman, S., N. Cohen, A. Yearim and G. Ast. 2013. DNA-methylation patterns on exon-intron structure and their effect on co-transcriptional splicing. Genome Research, 23:c789-99.

Ramalho, R. F., S. Gelfman, J. E.S. De Souza, G. Ast, S.J. De Souza and D. Meyer. 2013. Testing for natural selection in human exonic splicing regulators associated with evolutionary rate shifts. Journal of Molecular Evolution, 76: 228-39.

Gelfman, S., D. Burstein, O. Penn, A. Savchenko, M. Amit, S. Schwartz, T. Pupko and G. Ast. 2012. Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons. Genome Research 22: 35-50.

Amit, M., M. Donyo, D. Hollander, A. Goren, E. Kim, S. Gelfman, G. Lev-Maor, D. Burstein, S. Schwartz, and B. Postolsky, T. Pupko and G. Ast. 2012. Differential GC content between exons and introns establishes distinct strategies of splice-site recognition. Cell Reports, 1: 543-56.